2 instances of BRCM running

I am aware you should not be running two instances of BRCM, however, we have occasionally received the 2 instances error pop up even when there is clearly only one instance of the program running.  We can close the program and reopen and resume work.  

I'm just curious if there are known things that might be causing that error?  Is there any other situations that might cause this to appear?  We are running BRCM out of ProjectWise, if that matters.

Thanks